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It has been shown that multiple apoptosis-regulating proteins are substrates for lysosome-derived cathepsins, including Bid, Bcl-2, Bcl-XL, and XIAP [62]

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Komodo, 2024.

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The increased potencies of the IGF-I variants may relate to the substantially increased plasma levels of IGF-binding proteins, particularly IGFBP-3, produced by the combined treatment of dexamethasone with IGF-I or the variants